The release exponent n describing the mechanism of drug release from the matrices was calculated by regression analysis using the following equation. The films were stored in air tight plastic bags till further use4, 5. The films were allowed to dip in 40 mL of phosphate buffer pH 6. The percent moisture loss was calculated using following formula results are in table no. When the release data were fitted to Koresmeyer- Peppas release model and interpretation of release exponent values n enlightens in understanding the release mechanism from the dosage form
Mucoadhesive drug delivery systems. The dissolution time is the time when the film completely dissolves. The strength of the buccal films was determined by measuring tensile strength TS and percentage elongation. In therapeutic doses they decrease spasm of the gastrointestinal tract, biliary tract, ureter and uterus. This would increase the bioavailability of the drug at the required site of action and bring about immediate pharmacological action. Films formulated from PVA were smooth, flexible and transparent whereas those prepared from HPMC were slightly rough in texture, less flexible and translucent. Further, starch, sodium starch glycolate, and microcrystalline cellulose were the disintegrants added to different ratios, forming various formulations F1 to F7.
X1 formulation shows maximum in- vitro drug release The various parameters evaluated for all the formulated films are represented in Table 2. Aspartame used as a sweetener will successfully djssolving the bitter taste of the drug dicyclomine. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
The thickness of the films was measured by vernier caliper at three different positions on the film and the average was calculated. From the results of the tests for physical characterization conducted, it is observed that the weight and thickness of all film samples was uniform within each formulation.
Development of polymer-bound fast-dissolving metformin buccal film with disintegrants
Published 1 October Volume Received 9 January The drug-polymer compatibility was confirmed by taking IR spectrum and DSC thermogram of drug, polymer and physical mixture of drug-polymer proved that the excipients were compatible with the Dicyclomine as shown in figure: The folding endurance varied between and times, which is considered the sign of good flexibility, except for film F5, containing starch and MCC, which showed lower flexibility.
Hyperlink reference not valid. Oral film technology fulfills all the requirements of potential solid dosage form. Figure 4 Cumulative drug release of all buccal films F1—F7. Nagai T, Koshini R. fxst
Film Thickness The thickness of each of 10 film of each type of formulation was measured using a micrometer screw gauge6 and the average was determined as shown in Table no. In therapeutic doses they decrease spasm of the gastrointestinal tract, biliary tract, ureter and uterus.
The Physiodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Surface pH An acidic or alkaline bucccal of administered dosage forms can irritate the buccal mucosa.
Dissolvihg purpose of the study reported here was to develop a polymer-bound fast-dissolving buccal film of metformin to exploit these unique properties.
[Full text] Development of polymer-bound fast-dissolving metformin buccal film wit | IJN
Films were evaluated for mechanical properties, Morphology study, swelling properties, disintegration time, dissolution time and in- vitro drug release. The bucca of this study is to formulate thesos evaluate the FDOF of an anticholinergic drug Dicyclomine and improved bioavailability of drugs as compared to conventional solid oral dosage forms.
Although various parameters evaluated show optimum values as per the standard limits, the values seem to vary only slightly for formulations F1—F6, as compared to those for formulation F7.
It has been well known that after buccal and sublingual administration drug solutes didsolving rapidly absorbed in to the reticulated vein and are then drained into the systemic circulation2. Fast dissolving oral film FDOF is used as a novel approach, as it dissolve rapidly in mouth and directly reaches to the systemic circulation.
The assay of the chosen drug metformin hydrochloride was validated and found to be Development and evaluation of carvedilol transdermal patches. The percent moisture loss was calculated using following formula results are in table no.
Evaluation of free films. Films formulated from PVA were smooth, flexible and transparent whereas those prepared from HPMC were slightly rough in texture, less flexible and translucent. The release exponent n dissolvnig the mechanism of thesiss release from the matrices was calculated by regression analysis using the following equation.
The percent elongation was calculated by using formula- mm-2 as given below, and the results are shown in table no. Formulation and In vitro evaluation of taste masked orodispersible tablet of metoclopromide hydrochloride using indion The type of the polymer is characterized by following table:.
The drug content and content uniformity test was performed to ensure uniform distribution of drug. J Pharm Pharm Sci.
The bioavailability and disintegration properties of OTFs in saliva are increased by adding different ratios of super-disintegrants such as starch, sodium starch glycolate SSGand microcrystalline cellulose MCC. Eur J Pharmaceut and Biopharmaceut ; 70, —