Search Pubmed for Altalhab S. However, the psoriasis skin lesions may show no to minimal improvement upon treatment discontinuation of the suspected drug. Another drug that is commonly linked to an increased risk for psoriasis is terbinafine, a synthetic antifungal agent. Results of immunohistologic investigations. Summative statistics for our case series are listed in Table 2.

Closely related to the role of interferon-alpha in psoriasis development is imiquimod. Administrative, technical and material support: In addition, we included several reviews written on drug-induced psoriasis. Summative statistics for patients identified in the literature review are listed in Table 2. The first step in the management of drug-related psoriasis is stopping and replacing the offending agent when possible. Recruitment of immature plasmacytoid dendritic cells plasmacytoid monocytes and myeloid dendritic cells in primary cutaneous melanomas. J Am Acad Dermatol ;

Duration of therapy prior to the onset or worsening of psoriasis ranged from 2 weeks to 48 months. Am J Clin Dermatol ;9: Other clinical presentations included guttate and plaque psoriasis on the trunk and extremities and scalp psoriasis. Interferons have a well-known association with psoriasis development. reviee

[Full text] Drug-induced psoriasis: clinical perspectives | PTT

Paradoxical psoriasis in a large cohort of patients with inflammatory bowel disease receiving treatment with anti-TNF alpha: Nine of the 15 oiterature had pustular lesions on their palms and soles. Psoriasis induced by vedolizumab.


Abstract Fulltext Metrics Get Permission. Metoprolol-induced total body erythroderma. Exacerbation of psoriasis induced by interferon-alpha treatment for melanoma.

Palmoplantar pustular psoriasis induced by adalimumab: a case report and literature review.

Although well-conducted systematic studies on drug-related psoriasis are mostly lacking, traditionally strong associations have been documented for beta-blockers, lithium, antimalarial drugs such as hydroxy chloroquine, interferons, imiquimod, and terbinafine.

Induced psoriasis after rituximab therapy for rheumatoid arthritis: Clinicians should be aware of potential associations, but currently a practice gap exists in the recognition and management of drug-related psoriasis. There are few systematic studies on the histopathology of drug-induced psoriasis. C, Skin biopsy specimen showed psoriasiform epidermal hyperplasia with hyperkeratosis and confluent parakeratosis.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Paradoxical exacerbation of chronic plaque psoriasis by sorafenib. Imiquimod is a topical toll-like receptor Adalomumab 7 agonist that can activate cutaneous plasmacytoid dendritic cells to produce interferons.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Psoriasis is a chronic condition of still uncertain cause. Our website uses cookies to enhance your experience.

Treatment of psoriasis and psoriatic arthritis with interferon gamma. Back to top Article Information. Surprisingly, use of TNF-alpha inhibitors is associated with a risk of developing psoriasiform adverse events.

However, in some cases, so-called psoriasiform skin lesions are described.

palmoplantar pustular psoriasis induced by adalimumab a case report and literature review

Imiquimod-induced psoriatic erythroderma treated with infliximab. Data were available for 21 women and 11 men, ranging in age from 19 to 69 years data unavailable for the other 11 patients.


Palmoplangar, interferon-gamma, which was studied as a potential psoriasis treatment in the early s, has been described to induce psoriasis at the injection site of interferon-gamma. She resumed etanercept treatment and continued undergoing topical therapy for her skin disease. Patients usually present with sterile, intraepidermal pustules over palms and soles, and it is difficult to treat.

Drug-induced psoriasis: clinical perspectives

Recognizing potential drug-related psoriasis is of clinical relevance to allow an optimal management of psoriasis. Sody E, Korber A. Her skin eruptions improved, but her joint disease flared. Generalized pustular and erythrodermic psoriasis associated with bupropion treatment.

Severe pustular psoriasis provoked by oral terbinafine. The Mayo Clinic experience, to Psoriasis induced or aggravated by drugs.

Home Journals Why publish with us? She has not had a relapse of her psoriasis despite continuation of etanercept therapy.